Oxaliplatin can cause damage to peripheral nerves. The Oxaloplatin-Specific Neurotoxic Scale (OSNS) can be used to grade peripheral neuropathy.
Parameters:
(1) duration of dysestheia and/or paresthesia relative to therapeutic cycles
(2) functional impairment (disability)
Duration of Effects
Functional Impairment
Grade
absent
No
0
transient (completely gone before next cycle of therapy)
1
persists between cycles of therapy
2
Yes
3
where:
• The duration of persistent injury might vary. A case with Grade 3 injury could be prolonged.
• The severity of the functional impairment is not given and is presumed to be moderate to severe.
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Purpose: To evaluate a patient with peripheral neurotoxicity associated with oxaliplatin therapy using the OSNS grading scheme.
Specialty: Hematology Oncology, Neurology
Objective: criteria for diagnosis
ICD-10: G90.0,
