Nomogram Predicting Hepatotoxicity Following Acetaminophen Poisoning

Purpose: To determine the probability of serious hepatotoxicity in a patient who has taken an overdose of acetaminophen using the nomogram of Sivilotti et al.

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Evaluation

Are you evaluating a patient who has just taken an overdose of acetaminophen?

Yes

Time after drug ingestion that the serum acetaminophen levelis measured

hours

Serum acetaminophen level at that time

Time that N-acetylcysteine is given after drug ingestion

hours

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

LOG10 for estimated serum acetaminophen level when N-acetylcysteine is given

Estimated serum acetaminophen level when the N-acetylcysteine was given

The probability that the patient will develop a peak serum transaminase >= 1,000 IU/L is

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
Clinical Diagnosis, Including Family History For Genetics
- Clinical Findings of Opioid Toxicity in Patient Treated for Pain
- Pseudosepsis Syndrome in Salicylate Intoxication
Laboratory Tests
- Acetaminophen Serum Levels (Rumach-Matthew Nomogram)

Therapy

Selection
Dosage Calculations
- Clinical Findings of Opioid Toxicity in Patient Treated for Pain
Prevention
- Pulmonary Syndromes Complicating Salicylate Therapy

Monitoring

Adverse Effects
Overdose And Reversal
- When to Suspect Salicylate Intoxication in an Elderly Patient

Specialty

Toxicology
Emergency Medicine
Critical Care

Objective

risk factors
adverse effects

ICD-10

T39.1 - Poisoning, 4-aminophenol derivatives

Info

Purpose: To determine the probability of serious hepatotoxicity in a patient who has taken an overdose of acetaminophen using the nomogram of Sivilotti et al.

Specialty: Toxicology, Emergency Medicine, Critical Care

Objective: risk factors, adverse effects

ICD-10: T39.1,

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