Acetaminophen Induced Hepatotoxicity | Medical Algorithm

Are you evaluating a patient who presents with acetaminophen poisoning within a few hours after the overdose?

Yes

Has the patient taken multiple doses of acetaminophen over a short period of time?

Yes

Does the patient have a history of?

• chronic alcohol abuse?

Yes

• pre-existing liver diease (viral hepatitis, alcoholic hepatitis, other)?

Yes

• malnutrition?

Yes

• an eating disorder (anorexia, bulimia)?

Yes

• AIDS?

Yes

• malabsorption (cystic fibrosis, other)?

Yes

• an acute illness with prolonged vomiting or dehydration?

Yes

• starvation, fasting or an inability to eat?

Yes

Has the patient recently taken?

• carbamazepine?

Yes

• phenobarbital?

Yes

• primidone?

Yes

• rifampicin?

Yes

• isoniazid?

Yes

• omeprazole?

Yes

• oral contraceptives?

Yes

• St. John's Wort?

Yes

• other enzyme inducing drugs?

Yes

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Number of factors that may place the person at increased risk for severe hepatotoxicity

Should the patient be treated more aggressively to prevent hepatotoxicity?

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
Clinical Diagnosis, Including Family History For Genetics
- Clinical Findings of Opioid Toxicity in Patient Treated for Pain
- Pseudosepsis Syndrome in Salicylate Intoxication
Laboratory Tests
- Acetaminophen Serum Levels (Rumach-Matthew Nomogram)

Therapy

Selection
Dosage Calculations
- Clinical Findings of Opioid Toxicity in Patient Treated for Pain
Prevention
- Pulmonary Syndromes Complicating Salicylate Therapy

Monitoring

Adverse Effects
Overdose And Reversal
- When to Suspect Salicylate Intoxication in an Elderly Patient

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Therapy

Monitoring

Specialty

Objective

ICD-10

Risk Factors for Severe Hepatotoxicity in Patient with Acetaminophen (Paracetamol) Poisoning

Purpose: To identify a patient presenting soon after an acetaminophen overdose who may be at increased risk for hepatotoxicity.

Evaluation

Results

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Power Your Solutions with 5,000+ Automated Medical Analytics

Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Therapy

Monitoring

Specialty

Objective

ICD-10