Kantarjian et al proposed the Simplified Myelodysplastic Syndrome Risk Score. This is intended to address a number of deficiencies identified in the International Prognostic Scoring System (IPSS). The authors are from the University of Texas M.D. Anderson Cancer Center, University of Rochester, H.L. Moffitt Cancer Center, Hospital Avicenne (Paris) and University Hospital La Fe (Valencia, Spain).
Parameters:
(1) ECOG performance status
(2) age of the patient in years
(3) platelet count
(4) hemoglobin
(5) percent blasts in the bone marrow
(6) white blood cell count
(7) karyotype
(8) history of prior transfusion
|
Parameter |
Findings |
Points |
|
ECOG performance scale |
0 or 1 |
0 |
|
|
2 to 4 |
2 |
|
age in years |
< 60 years |
0 |
|
|
60 to 64 years |
1 |
|
|
>= 65 years |
2 |
|
platelet count |
>= 200,000 per µL |
0 |
|
|
50,000 - 199,999 per µL |
1 |
|
|
30,000 - 49,999 per µL |
2 |
|
|
< 30,000 per µL |
3 |
|
hemoglobin |
>= 12 g/dL |
0 |
|
|
<12 g/dL |
2 |
|
percent blasts in bone marrow |
< 5% |
0 |
|
|
5 - 10% |
1 |
|
|
11 - 29% |
2 |
|
white blood cell count |
<= 20,000 per µL |
0 |
|
|
> 20,000per µL |
2 |
|
karyotype |
chromosome 7 abnormality |
3 |
|
|
>= 3 abnormalities (complex) |
3 |
|
|
other |
0 |
|
history of previous transfusion |
no |
0 |
|
|
yes |
1 |
where:
• 30% bone marrow blasts or higher indicates acute leukemia.
simplified score =
= SUM(points for all 8 parameters)
Interpretation:
• minimum score: 0
• maximum score: 15
• The higher the score the greater the risk.
|
Total Score |
Risk Group |
Median Survival |
|
0 to 4 |
low |
54 months |
|
5 or 6 |
intermediate-1 |
25 months |
|
7 or 8 |
intermediate-2 |
14 months |
|
>= 9 |
high |
6 months |
Purpose: To evaluate a patient for the myelodysplastic syndrome using the Simplified Score of Kantarjian et al.
Specialty: Hematology Oncology, Clinical Laboratory
Objective: risk factors
ICD-10: D46,
