The MACIS (metastasis, age, completeness of resection, invasion, size) prognostic score can be used to predict prognosis in patients with papillary carcinoma of the thyroid.
Parameters found to independent predictive variables in papillary carcinomas of the thyroid:
(1) age
(2) tumor size
(3) local invasion (extrathyroidal)
(4) distant metastases
These were used to develop a prognostic score, with the addition of a fifth parameter for completeness of surgical resection.
Parameter
Finding
Points
distant metastasis
distant metastases present
3
distant metastases absent
0
age
<= 39
3.1
>= 40
0.08 * (age)
completeness of resection
incompletely resected
1
completely resected
0
invasion
local invasion present
1
local invasion absent
0
size
diameter in centimeters
0.3 * (diameter)
MACIS score =
= (points for metastasis) + (points for age) + (points for completeness of resection) + (points for invasion) + (points for size)
Interpretation:
• minimum score 3.14 [3.1 + (0.3 * 0.1)]
• maximum score > 13
• The higher the score, the worse the prognosis.
MACIS Score
20 Year Survival Rate
< 6.00
99%
6.00 - 6.99
89%
7.00 - 7.99
56%
>= 8.00
24%
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