The EORTC Thyroid Cancer Group developed a prognostic index for patients with thyroid carcinoma. It uses survival from all causes of death as the endpoint.
Parameters at time of initial diagnosis:
(1) age
(2) gender
(3) histologic type
(4) T category from 1968 TNM classification
(5) distant metastases
|
Parameter |
Finding |
Points |
|---|---|---|
|
age |
age in years |
(age) |
|
gender |
male |
12 |
|
|
female |
0 |
|
histologic type |
anaplastic as principal or secondary pattern |
45 |
|
|
medullary |
10 |
|
|
less-differentiated follicular as principal pattern |
10 |
|
|
other |
0 |
|
T category for 1968 TNM |
3 |
10 |
|
|
0, 1, 2 |
0 |
|
metastases |
none |
0 |
|
|
1 |
15 |
|
|
>= 2 |
30 |
where:
• T3 code for 1968 TNM classification = extension beyond the thyroid glands with fixation or infiltration of adjacent structures; this corresponds to the current T4. T0 = nonpalpable; T1 = mobile, limited to thyroid, with no deformity; T2 = single or multiple mobile tumors deforming the gland
EORTC prognostic index =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: depends on age of patient (could be < 20)
• maximum score: depends on age of patient (could be > 150)
|
Index |
Risk Group |
Observed 5 Year Survival |
|---|---|---|
|
< 50 |
1 |
95% |
|
50 – 65 |
2 |
80% |
|
66 – 83 |
3 |
51% |
|
84 – 108 |
4 |
33% |
|
>= 109 |
5 |
5% |
Limitations:
• The index was described in 1979. The expected survival has probably improved since then.
Purpose: To estimate prognosis in a patient with thyroid carcinoma using the EORTC prognostic index of 1979.
Specialty: Hematology Oncology, Surgery, general, Endocrinology
Objective: severity, prognosis, stage
ICD-10: C73,
