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Risk Factors for Overall Survival in Child with Chronic Graft-versus-Host Disease

Purpose: To identify factors impacting survival of a pediatric patient with chronic graft-versus-host disease (GVHD) based on the study of Jacobsohn et al.

Description

Jacobsohn et al identified risk factors affecting overall survival of pediatric patients with chronic graft-versus-host disease (GVHD). These can help to identify patients who may benefit from more aggressive management. The authors are from multiple hospitals in the United States and Europe.


 

Patient selection: allogeneic hematopoietic stem cell transplant (HSCT)

Transplant: allogeneic donor or umbilical cord blood

Risk Factor

Poor Overall Survival

Increased Nonrelapse Mortality (NRM)

age

> 10 years

NA

disease status at transplantation

advanced

NA

donor match for transplant

mismatched or partially matched unrelated donor

mismatched or partially matched unrelated donor

Karnofsky score at diagnosis of chronic GVHD

< 80

< 80

platelet count at diagnosis of chronic GVHD

< 100,000 per µL

< 100,000 per µL

source of graft material

NA

peripheral blood

 


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Specialty

Objective

ICD-10