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Criteria for Essential Cryoglobulinemic Vasculitis

Purpose: To evaluate a patient with a vasculitis for features of essential cryoglobulinemic vasculitis.

Description

Criteria for the diagnosis of essential cryoglobulinemic vasculitis were proposed at an International Consensus Conference held at the University of North Carolina, Chapel Hill, North Carolina.


 

Lesion: vasculitis affecting small blood vessels

Vessel

Involvement

venules

yes

capillaries

yes

arterioles

yes

small arteries

possibly

medium-sized arteries

no

large arteries

no

 

Features:

(1) cryoglobulin deposits in the vascular lesions

(2) cryoglobulin in the serum

(3) glomerulonephritis

(4) skin involvement

 

Differential diagnosis:

(1) Henoch Schonlein purpura - IgA immune deposits

(2) microscopic polyangiitis - no or rare immune deposits

(3) serum sickness - immune complex deposits

(4) SLE - positive ANA

 


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Specialty

Objective

ICD-10