Clinical Findings in Patient with Cryofibrinogen

• metastatic malignant disease?

• an autoimmune disease?

• multiple myeloma?

• purpura or ecchymoses, especially in cold weather?

• retinal hemorrhages or retinal vein thrombosis?

• digital gangrene or ulceration?

• amorphous globules seen in the peripheral blood smear?

• a falsely elevated WBC count when a chilled specimen is run on an automated cell counter?

• prolonged thrombin time on a refigerated specimen collected in citrate?

• decreased fibrinogen in a refigerated specimen collected in citrate?

• much shorter thrombin time on a specimen collected in citrate and kept at 37°C?

• much higher fibrinogen level in a specimen collected in citrate and kept at 37°C?