Clinical Risk Factors for Adenocarcinoma Arising in Barrett's Esophagus

Parameter

Low Risk

Intermediate Risk

High Risk

age in years

< 40

40 – 45

> 45

gender

female

male

length of Barrett's metaplasia in cm

< 3 cm

3 – 8 cm

> 8 cm

reflux

mild, < 1 per week

severe <= 3 times per week; moderate; mild >= 1 per week

severe, > 3 times per week

chronicity in years

< 1 years

1 – 10 years

> 10 years

race

black

white

body weight

normal weight

obese

family history

none

gastric cancer

drug therapy

NSAIDS

nitrates, theophylline, anticholinergics, benzodiazepines

H. pylori disease

present

absent

smoking

none

light smoker

heavy smoker

mucosal damage

intact

ulceration or stricture in metaplastic epithelium