Chronic Nonbacterial Osteomyelitis (CNO) Clinical Features

Age of the patient at onset of symptoms

Number of lytic bone lesions

Does the patient have pain and swelling associated with bone lesion(s)?

Has the condition had remissions and exacerbations?

Does an X-ray of the bone lesion show osteolysis with sclerosis?

Have blood and/or bone cultures been positive for bacteria and fungi ?

Does histologic examination of a bone biopsy shows acute or subacute inflammation?

Does histologic examination of a bone biopsy shows evidence of a bone tumor

Does the patient have elevated acute phase reactants during an exacerbation?