Wisconsin Index (WIN) of Mazeh et al for Evaluating a Patient with Hyperparathyroidism

Description

Mazeh et al reported a nomogram to predict the presence or additional hyperfunctioning parathyroid glands during parathyroidectomy. This is based on a Wisconsin Index and weight of the removed parathyroid glands. The authors are from the University of Wisconsin in Madison.

Patient selection: hyperparathyroidism

Parameters:

(1) preoperative serum total calcium in mg/dL

(2) preoperative parathyroid hormone level in pg/dL

(3) parathyroid gland weight in milligrams

index =

= (serum calcium) * (preoperative parathyroid level)

Index	Level
< 800	low
800 to 1600	medium
> 1600	high

Confirmation of no further hyperfunctioning parathyroid glans was a >= 50% decrease in intraoperative PTH levels after removal of a parathyroid gland.

Weight	High	Medium	Low
100	97	94	83
200	80.7	62.2	38.5
300	74	43.1	18.7
400	67.3	33	14.7
500	62.4	23.9	8.6
600	55	18.3	8.1
800	38.5	9.5	4.6
1000	19	2	0

This is approximated by:

Gland Weight	Probability Multiple Glands for High Curve
100 to 200	113.3-(0.163 * (weight))
200 to 1000	(-0.00003129 * ((weight)^2)) - (0.03826 * (weight)) + 88.84

Gland Weight	Probability Multiple Glands for Medium Curve
100 to 300	(0.000434 * ((weight)^2)) - (0.428 * (weight)) + 132.5
300 to 1000	(0.00005865 * ((weight)^2)) - (0.1331 * (weight)) + 77.08

Gland Weight	Probability Multiple Glands for Low Curve
100 to 500	(-0.00000222 * ((weight)^3)) + (0.002662 * ((weight)^2)) - (1.094 * (weight)) + 168.1
500 to 1000	(-0.00002121 * ((weight)^2)) + (0.01422 * (weight)) + 6.942

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Wisconsin Index (WIN) of Mazeh et al for Evaluating a Patient with Hyperparathyroidism

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