A patient with Wilson's disease may present with hepatobiliary disease. Hepatobiliary disease is a common presentation for children, adolescents and young adults with Wilson's disease.
(1) acute fulminant hepatitis
(2) acute hepatitis mimicing drug or viral hepatitis
(3) acute hepatitis mimicing autoimmune hepatitis
(4) acute cholelithiasis
(1) chronic hepatitis
(2) cirrhosis with portal hypertension
(3) recurrent episodes of jaundice
(4) chronic cholelithiasis/cholecystitis associated with chronic hemolytic anemia
Reasons to consider Wilson's disease:
(1) young age at onset
(2) family history of Wilson's disease
(3) exclusion of drug, viral and autoimmune causes
(4) other manifestations of Wilson's disease (neuropsychiatric, Kayser-Fleischer rings, unexplained hemolytic anemia, other)
Needless to say it is easy to miss the diagnosis.
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Purpose: To evaluate a patient presenting with hepatobiliary disease for findings that may suggest Wilson's disease.
Objective: severity, prognosis, stage, disease progression