WHO Prognostic Index Score for Gestational Trophoblastic Disease

age in years

<= 39

0

> 39

1

antecedent pregnancy

hydatidiform mole

0

abortion or ectopic

1

term pregnancy

2

interval in months between end of antecedent pregnancy & start of chemotherapy

< 4

0

4 - 6

1

7 - 12

2

> 12

4

beta-HCG in IU/L

< 1,000

0

1,000 - 10,000

1

10,000 - 100,000

2

> 100,000

4

ABO blood group

patient O & partner A;

patient A & partner O

1

patient B or AB

2

largest tumor, including uterine tumor

< 3 cm

0

3 - 5 cm

1

> 5 cm

2

site of metastases

none, or other sites

0

spleen, kidney

1

GI tract, liver

2

brain

4

number of metastases

none

0

1 - 4

1

4 - 8

2

> 8

4

prior chemotherapy

none

0

single drug

2

2+ drugs

4