WHO Criteria for Acute and Subacute Hematologic Toxic Effects of Cancer Therapy in Adults

Parameters

Grade 0

(1) hemoglobin

>= 11 g/dL

(2) WBC count (leukocytes)

>= 4,000 per µL

(3) absolute granulocyte count

>= 2,000 per µL

(4) platelet count

>= 100,000 per µL

(5) clinical hemorrhage

none

Parameter

Finding

Grade

hemoglobin

>= 11 g/dL

0

9.5 – 10.9 g/dL

1

8.0 – 9.4 g/dL

2

6.5 – 7.9 g/dL

3

< 6.5 g/dL

4

WBC count

>= 4,000 per µL

0

3,000 – 3,900 per µL

1

2,000 – 2,999 per µL

2

1,000 to 1,999 per µL

3

< 1,000 per µL

4

absolute granulocyte count

>= 2,000 per µL

0

1,500 – 1,900 per µL

1

1,000 – 1,400 per µL

2

500 – 999 per µL

3

< 500 per µL

4

platelet count

>= 100,000 per µL

0

75,000 – 99,999 per µL

1

50,000 – 74,999 per µL

2

25,000 – 49,999 per µL

3

< 25,000 per µL

4

hemorrhage

none

0

petechiae

1

mild blood loss

2

gross blood loss

3

debilitating blood loss

4