Are you evaluating a patient for findings of CNS involvement in Whipple's disease?

Has the patient shown?

• cognitive decline with disorientation and memory loss?

• progression to dementia?

• personality changes?

• seizures?

• oculmasticatory myorhythmias?

• focal neurologic findings?

• progressive hypersomnia and/or hyperphagia?

• supranuclear ophthalmoplegia and/or nystagmus?

• ataxia?

• incontinence?

Do imaging studies show focal lesions?

• hypothalamus and thalamus?

• mamillary bodies?

• cingulate gyrus?

• basal ganglia?

• insular cortex?

• cortex of the cerebellum?


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