Whipple Disease Clinical Features Central Nervous System Involvement

Are you evaluating a patient for findings of CNS involvement in Whipple's disease?

Yes

Has the patient shown?

• cognitive decline with disorientation and memory loss?

Yes

• progression to dementia?

Yes

• personality changes?

Yes

• seizures?

Yes

• oculmasticatory myorhythmias?

Yes

• focal neurologic findings?

Yes

• progressive hypersomnia and/or hyperphagia?

Yes

• supranuclear ophthalmoplegia and/or nystagmus?

Yes

• ataxia?

Yes

• incontinence?

Yes

Do imaging studies show focal lesions?

• hypothalamus and thalamus?

Yes

• mamillary bodies?

Yes

• cingulate gyrus?

Yes

• basal ganglia?

Yes

• insular cortex?

Yes

• cortex of the cerebellum?

Yes

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Specialty

Objective

ICD-10

Whipple's Disease Clinical Features of Central Nervous System Involvement

Purpose: To evaluate a patient for central nervous system involvement in Whipple's disease.