Non-celiac wheat sensitivity is newly recognized food sensitivity distinct from celiac sprue. Carroccio et al identified a number of features seen in affected patients. The authors are from multiple hospitals in Agrigento and Palermo, Italy.


Features of non-celiac wheat sensitivity may include:

(1) symptoms resembling those of irritable bowel syndrome (IBS)

(2) resolution of symptoms on gluten-free diet

(3) reappearance of symptoms on wheat challenge

(4) history of food allergy during infancy

(5) coexistent atopy

(6) absence of villous atrophy in small bowel biopsy

(7) infiltration of duodenal and colonic mucosa with eosinophils

(8) T-cell infiltrate of small bowel mucosa (> 25 CD3 positive lymphocytes per 100 enterocytes)

(9) anti-gliadin antibodies

(10) negative serum anti-transglutaminase and anti-endomysium IgA antibodies

(11) DQ2 or DQ8 haplotype

(12) negative skin prick and RAST tests to wheat (IgE-mediated)


The condition may have several subtypes:

(1) group with some features of celiac disease

(2) group with multiple food sensitivities


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