The American Academy of Pediatrics (AAP) issues guidance for managing a neonate with possible sepsis.


Indications of lumbar puncture if the procedure can be performed safely:

(1) clinically septic

(2) positive blood culture

(3) probably septic based on laboratory test results

(4) not responding as expected to antimicrobial therapy


A lumbar puncture may not be needed if:

(1) Sepsis is suspected but the infant is healthy-looking.

(2) The procedure may not be safe to perform.


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