Hoff et al used a weight-based extended-interval dosing protocol for gentamicin in critically-ill neonates. A simple protocol can often perform adequately. The authors are from Children's Hospital and Clinics of Minnesota in Minneapolis.


Patient selection: neonate receiving intensive care


Targets: peak plasma gentamicin concentration of 7-10 mg/L with trough concentrations less than 2 mg/L



(1) body weight at birth in grams

(2) concurrent therapy with indomethacin


Basic dose: 4 mg per kg given intravenously

Patient Feature

Interval Between Doses

< 1,250 g at birth

every 48 hours

indomethacin therapy

every 48 hours


every 24 hours


Plasma trough and peak levels should be used to refine the drug regimen.


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