The volume-oxygenation (VOX) index can help to identify a patient with acute hypoxemia and respiratory failure who may fail high-flow nasal cannula (HFNC) oxygen therapy. The authors are from Southeast University in Nanjing and Erasmus University.
Patient selection: high-flow nasal cannula (HFNC) for acute hypoxemia respiratory failure
Parameters:
(1) SpO2 to FIO2 ratio
(2) tidal volume in in mL per kg (VT)
VOX index =
= (SpO2 to FIO2 ratio) / (VT)
Time
Low Risk Failure High Flow Nasal Cannula
0 hours
VOX > 24.82
2 hours
VOX > 20.91
6 hours
VOX> 22.67
Performance:
• The area under the ROC curve at 0 and 2 hours was 0.83.
• The area under the ROC curve at 6 hours was 0.93.
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Specialty: Pulmonology
