Voriconazole is a triazole antifungal agent whose serum level is affected by the patient's genotype for CYP2C19.
CYP2C19 genotypes:
(1) homozygous extensive metabolizer
(2) heterozygous metabolizer (extensive and poor)
(3) homozygous poor metabolizer
CYP2C19 Genotype
Serum Voriconazole Level
Implication
homozygous extensive
reference level
heterozygous
2 times higher
lower dose required
homozygous poor
4 times higher
much lower dose required
In the United States the homozygous poor metabolizer is uncommon, while this is relatively common in Asia.
Racial Group
Homozygous Extensive
Heterozygous
Homozygous Poor
White
75%
23%
2%
Black
Chinese or Japanese
35%
45%
20%
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Specialty: Toxicology, Emergency Medicine, Critical Care, Genetics
ICD-10: ,
