Copp et al identified factors associated with noncompliance in children taking prophylactic antibiotics for vesicoureteral reflux (VUR). Failure to take the prophylactic antibiotics is a reason for recurrent urinary tract infections (UTI) in these patients. The authors are from Stanford University and Children's Hospital Boston.


Factors associated with compliance:

(1) younger age (age <= 5 years of age)

(2) moderate to severe disease

(3) 1 or more urologist visits in the past year

(4) 1 or more hospitalizations in the past year

(5) 2 or more changes in the antibiotic regimen in the past year



• The change in antibiotic visits may correlate with contact with healthcare providers or more severe disease.


Only 40% of patients prescribed prophylactic antibiotics were compliant.


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