Verruciform xanthomas may occur in the genital region of men and women. These resemble verruciform xanthomas of the oral cavity.
Pathogenesis: most patients do not have hyperlipidemia or other systemic disease that can explain the lesions
Locations:
(1) scrotum
(2) penis
(3) vulva
Clinical appearance: wart-like skin lesion
Histologic appearance:
(1) foamy macrophages within elongated dermal papillae
(2) epithelial acanthosis
(3) variable hyperkeratosis
Differential diagnosis:
(1) HPV-related verruca (mixed lesions possible)
(2) skin tag (acrochordon)
