Risk factors associated with the patient:
(1) advanced age (will use > 65 years in the implementation)
(2) Afro-American
(3) past history of venous and/or arterial thromboembolism
(4) hereditary or acquired hypercoagulable state (Factor V Leiden, etc)
(5) thrombocytosis prior to chemotherapy
(6) obesity
(7) active infection
(8) comorbid organ dysfunction (renal, pulmonary, stroke, etc)
where:
• The risk for thromboembolism is lower in Asians and Pacific Islanders.
Risk factors associated with the malignancy:
(1) presence of metastatic disease
(2) <= 6 months since initial cancer diagnosis
(3) site of the primary cancer: lung, gastrointestinal tract, brain, renal, leukemia, lymphoma, gynecologic
Risk factors associated with medications:
(1) current chemotherapy
(2) current hormonal therapy
(3) recent antiangiogenic therapy (thalidomide, lenalidomide, bevacizumab)
(4) current erythropoietin therapy
Risk factors associated with non-medication management:
(1) presence of a central intravascular catheter
(2) recent major surgery
(3) current hospitalization
Additional risk factors not listed:
(1) immobilization
(2) trauma with tissue necrosis (brain trauma, lung contusion, etc)
(3) tumor-related stasis (compression on veins, etc)
(4) peripheral vascular grafts
The greater the number of risk factors the greater the risk of venous thromboembolism.
