Venlafaxine is an antidepressant. Discontinuation of therapy may be associated with a withdrawal syndrome.

Effects: inhibition of serotonin reuptake and inhibitor of norepinephrine


Clinical features:

(1) abrupt discontinuation following long-term therapy, even with low doses

(2) new onset of a variety of signs and symptoms

(3) exclusion of alternative explanations

(4) gradual resolution if no venlafaxine given or rapid resolution if drug restarted


Signs and symptoms may include:

(1) disturbed sleep

(2) headache

(3) nausea

(4) dysphoria

(5) positional vertigo

(6) irritability

(7) light headedness

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