Parameters:
(1) body weight of the patient in kilograms
(2) inotropicic score in µg per kg per min (see previous section)
(3) dose of vasopressin in units per minute
(4) milrinone dose in µg per minute
(5) norepinephrine in µg per minute
inotrope equivalence of vasprressin in µg per minute =
= 10000 * (vasopressin dose in units per minute)
inotrope equivalence of milrinone in µg per minute =
= 10 µg per minute for each µg per minute =
= 10 * (milrinone dose in µg per minute)
inotrope equivalence of norepinephrine in µg per minute =
= 10 µg per minute for each 0.1 µg per minute =
= 100 * (norepinephrine dose in µg per minute)
vasoactive inotropic score in µg per kg per min =
= ((dose of dopamine) + (dose of dobutamine) + (inotropic equivalence for epinephrine) + (inotropic equivalence for vasopressin) + (inotropic equivalence for milrinone) + (inotropic equivalence for norepinephrine)) / (body weigh in kilograms)
Interpretation:
• The higher the VIS the worse the prognosis.
• The maximum VIS had the best performance, with an ROC area of 0.83.
• A maximum VIS group of 4 or 5 (high VIS) was associated with a worse outcome.
|
VIS in the First 24 Hours
|
VIS in Second 24 Hours (24 to 48 Hours)
|
Group
|
|
< 10
|
< 5
|
1 (low VIS)
|
|
10 to 14
|
5 to 9
|
2 (low VIS)
|
|
15 to 19
|
10 to 14
|
3 (lowVIS)
|
|
20 to 24
|
15 to 19
|
4 (high VIS)
|
|
>= 25
|
>= 20
|
5 (high VIS)
|
where:
• The range for the VIS in the second 24 hours is that of the first 24 hours minus 5.
