Some patients with myelodysplasia or chronic myelomonocytic leukemia (CMML) develop a vasculitis as a paraneoplastic manifestation. Patients with vasculitis had a higher rate of progression to acute leukemia.
Features:
(1) presence of myelodysplasia or CMML
(2) onset of vasculitis just before or soon after onset of the blood disorder
(3) improvement of the vasculitis with treatment of the blood disorder
Types of vasculitis include:
(1) giant cell arteritis (GCA)
(2) ANCA-positive vasculitis (microscopic polyangiitis, granulomatosis with polyangiitis)
(3) leukocytoclastic skin vasculitis
(4) polyarteritis nodosa (PAN)
(5) cryoglobulinemia vasculitis
(6) Behcet's syndrome
(7) vasculitis not meeting criteria for a specific type
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