Leukocytoclastic vasculitis (angiitis) may follow vaccination.

Vaccines reported to cause include:

(1) COVID-19

(2) influenza

(3) HBV

(4) HPV


Mechanism: probably immune complex deposition


Clinical findings:

(1) purpuric papules which may be palpable

(2) erythematous macules


This may be a new-onset or exacerbation of existing leukocytoclastic vasculitis.


Skin biopsy may show:

(1) a perivascular inflammatory infiltrate with neutrophils and eosinophils

(2) red blood cell extravasation

(3) variable fibrinoid necrosis of vessel wall


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