A patient with a mutation in SCN1A (sodium voltage-gated channel alpha subunit) may experience seizures triggered by vaccination.

Gene location: 2q24.3


Seizures associated with SCN1A mutations include:

(1) simple febrile seizures

(2) seizures after vaccination

(3) simple myoclonic epilepsy of infancy (Dravet syndrome)

(4) myoclonic-astatic epilepsy

(5) intractable infantile partial seizures

(6) intractable childhood epilepsy with generalized tonic-clonic seizures

(7) generalized epilepsy with febrile seizures plus


When to suspect SCN1A-related seizures:

(1) family history of epilepsy, especially if more than one type

(2) febrile seizures during infancy or after 6 years of age

(3) febrile seizures that are severe

(4) seizures triggered by environmental stimuli (temperature change, bright lights, etc)

(5) intractable seizures during infancy or childhood

(6) family or personal history of seizures triggered by vaccination

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