Uthoff noticed that patients with multiple sclerosis (MS) may have a decrease in vision associated with a change in body temperature.


Conditions that may cause an increase in body temperature:

(1) exercise

(2) use of the sauna

(3) fever

(4) bathing in hot water


Features of the phenomenon:

(1) during an increase in body temperature the patient notices "black spots" in the visual fields of one or both eyes or a decrease in visual acuity

(2) vision returns to normal once the body temperature returns to normal


Other visual problems that occur in MS patients during a rise in body temperature:

(1) nystagmus

(2) abnormalities in saccadic velocity and pursuit eye movements


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