Use of the Graded Prognostic Assessment (GPA) for a Patient with Brain Metastases from a Breast Carcinoma

Description

Sperduto et al developed the Graded Prognostic Assessment (GPA) to evaluate patients with brain metastases (see 27.54.46). Later different scores were developed for various primary sites. The authors are from the University of Minnesota and Ridgeview Medical Center in Minnesota.

Patient selection: breast carcinoma

Parameters:

(1) Karnofsky Performance Scale (KPS)

(2) age in years

(3) cancer subtype

Parameter	Finding	Points
KPS	90 or 100	1.5
	70 or 80	1
	60	0.5
	10 to 50	0
age in years	< 60	0.5
	>= 60	0
cancer subtype	luminal B	2
	HER2 positive	1.5
	luminal A	1
	basal	0

total GPA =

= SUM(points for all 3 parameters)

Interpretation:

• minimum score: 0

• maximum score 4

• The higher the GPA the better the prognosis.

GPA	Median Survival
0, 0.5, 1.0	3.4 months
1.5, 2.0	7.7 months
2.5, 3.0	15.1 months
3.5 or 4.0	25.3 months

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Description

Specialty

ICD-10