Sperduto et al developed the Graded Prognostic Assessment (GPA) to evaluate patients with brain metastases (see 27.54.46). Later different scores were developed for various primary sites. The authors are from the University of Minnesota and Ridgeview Medical Center in Minnesota.
Patient selection: breast carcinoma
Parameters:
(1) Karnofsky Performance Scale (KPS)
(2) age in years
(3) cancer subtype
Parameter |
Finding |
Points |
KPS |
90 or 100 |
1.5 |
|
70 or 80 |
1 |
|
60 |
0.5 |
|
10 to 50 |
0 |
age in years |
< 60 |
0.5 |
|
>= 60 |
0 |
cancer subtype |
luminal B |
2 |
|
HER2 positive |
1.5 |
|
luminal A |
1 |
|
basal |
0 |
total GPA =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score 4
• The higher the GPA the better the prognosis.
GPA |
Median Survival |
0, 0.5, 1.0 |
3.4 months |
1.5, 2.0 |
7.7 months |
2.5, 3.0 |
15.1 months |
3.5 or 4.0 |
25.3 months |
Specialty: Hematology Oncology, Surgery, general
ICD-10: ,