Use of Serum FABP1 Concentrations to Predict Outcome Associated with Acetaminophen-Induced Acute Liver Failure (ALF)

Description

Karvellas et al correlated survival with the serum concentration of FABP1 in patients with acetaminophen-associated acute liver failure. Serum concentrations of FABP1 can help to identify patients who may require moer aggressive management such as hepatic transplantation. The authors are from the U.S. Acute Liver Failure Study Group (ALFSG)

FABP1 = liver-type fatty acid binding protein

Analysis: ELISA

Patient selection: acetaminophen-induced acute liver failure

Parameters:

(1) serum FABP1 concentration on day 1 (early)

(2) serum FABP1 concentration on day 3 to 5 (late)

Parameter	Finding	Points
early FABP1	<= 350 ng/mL	0
	> 350 ng/mL	1
late FABP1	<= 350 ng/mL	0
	> 350 ng/mL	1

total score =

= SUM(points for the 2 parameters)

Interpretation:

• minimum score: 0

• maximum score: 2

• An elevated serum FABP1 is associated with a worse 21-day mortality.

To read more or access our algorithms and calculators, please log in or register.

Use of Serum FABP1 Concentrations to Predict Outcome Associated with Acetaminophen-Induced Acute Liver Failure (ALF)

Description

Specialty