Grattan et al used the change urticaria activity score (UAS) to describe the response of a patient with chronic urticaria to therapy. The authors are from West Norwich Hospital, St. John's Institute of Dermatology and King's College in England.
Parameters:
(1) baseline urticaria activity score (UAS)
(2) urticaria activity score after an adequate trial of therapy
ratio of current to baseline UAS =
= (current UAS) / (baseline UAS)
Response criteria of Grattan et al
Ratio
Response
< 25%
response
> 75%
relapse
Response criteria expanded to include likely data
Ratio
Response
0% (current UAS 0)
complete
> 0 and < 25%
positive response
25 to 75%
partial response
> 75% (after initial response)
relapse
> 75% (with no initial response)
persistent or stable
> 120%
progression
where:
• The baseline UAS can range from 0 to 42 for a weekly UAS. The baseline needs to be above a certain level (? 14) to show a significant change.
• The patient should be assessed after an adequate therapeutic trial.
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