Description

Porter et al reported criteria for the cytokine release syndrome (CRS) associated with CAR T-cell therapy. The authors are from the University of Pennsylvania.


Parameters:

(1) severity of the reaction

(2) organ dysfunction

(3) hospitalization

(4) hypotension

(5) hypoxia

 

Severity

Organ Dysfunction

Hospitalize

Hypotension

Hypoxia

Grade

mild

no

no

no

no

1

moderate

moderate

NA

NA

no

2

moderate

NA

yes

NA

no

2

moderate

NA

yes

fluid resusc

no

2

severe

severe

yes

NA

NA

3

severe

NA

yes

low dose

NA

3

severe

NA

yes

NA

suppl O2

3

life threaten

severe

yes

high dose

NA

4

life threaten

severe

yes

NA

mech vent

4

 

Organ dysfunction:

(1) for grade 2: creatinine grade 2 or liver function tests grade 3

(2) for grade 3: creatinine grade 3 or liver function tests grade 4 or coagulopathy

 

Hypotension:

(1) for grade 2: fluid resuscitation

(2) for grade 3: low-dose vasopressors

(3) for grade 4: high-dose vasopressors

 

The diagnosis requires exclusion of an alternative explanation for the clinical findings.


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