Carbone et al reported the UK-PBC score for evaluating patients with primary biliary cholangitis. These can help to identify patients who may benefit from more aggressive management. The authors are members of the UK-PBC Consortium from multiple institutions in the United Kingdom.
Parameters:
(1) serum alkaline phosphatase after 12 months of UDCA as multiple of upper limit of normal, use IU/L
(2) serum transaminase (TA = ALT if available else AST after 12 months of UDCA as multiple of upper limit of normal, use IU/L
(3) serum total bilirubin after 12 months of UDCA as multiple of upper limit of normal, use µmol/L
(4) serum albumin as multiple of lower limit of normal (timing not stated), use g/L
(5) platelet count as multiple of lower limit of normal (timing not stated), use 10^9/L
value as multiple of upper limit of normal =
= (value) / (upper limit of normal)
value as multiple of lower limit of normal =
= (value) / (lower limit of normal)
score =
= A + B + C + D + E
A = 0.0287854 * ((alkaline phosphatase ratio) -1.722136304)
B= (-0.0422873) * ((((transaminase ratio) /10)^-1) - 8.675729006)
C = 1.4199 * (LN((bilirubin ratio) /10) + 2.709607778)
D = (-1.960303) * ((albumin ratio) - 1.17673001)
E = (-0.4161954) * ((platelet ratio) - 1.873564875)
Baseline survival functionsL
(1) 5 year survival: 0.982
(2) 10 year survival: 0.941
(3) 15 year survival: 0.893
survival function =
= (survival function for time interval)^EXP(score)
