Rarely a hereditary deficiency may affect 2 or more different coagulation factors. This may be due to multiple mutations or a single mutation that impacts multiple factors.
These disorders affect siblings or other close family members.
Patients may have a severe bleeding disorder.
Deficient Factors
Abnormal Tests
Other Deficiencies
Type
V and VIII
PT and aPTT
I
VIII and IX
aPTT
II
II, VII, IX, X
PT and aPTT
proteins S and C
III
VII and VIII
PT and aPTT
IV
VIII, IX and XI
aPTT
V
IX and XI
aPTT
V1
VIII and X
PT and aPTT
VII
where:
• All of the deficient elements in Type III are vitamin K dependent.
• 5 of the 7 types involve Factor VIII.
• 5 of the 7 types involve 2 factors, 1 type involves 3 and 1 type involves 4.
