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Tumor Flare Syndrome | Metastatic Carcinoma to Bone

Purpose:

To evaluate a patient with metastatic carcinoma to bone for the tumor flare reaction to therapy.

Specialty:

Hematology Oncology
Orthopedic Surgery

Objective:

criteria for diagnosis, adverse effects

ICD-10:

T45.1, T66

Description:

The Tumor Flare Syndrome describes a reaction in patients with metastatic carcinoma to bone within a few weeks of starting therapy. The symptoms may be severe but typically last only a few weeks. Patients who have had a flare reaction tend to have a beneficial response to the therapy, and it is important not to stop therapy prematurely.

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