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Description

Zahn et al reported a Tuberculosis Risk Score based on a patient's laboratory values. The score appears to predict outcome following antituberculous therapy. The authors are from Nanjing Medical University in China.


Patient selection: tuberculosis, prior to antituberculous therapy

 

Parameters:

(1) platelet count in 10^9/L

(2) packed cell volume (PCV, hematocrit) as a decimal fraction

(3) absolute lymphocyte count in 10^9/L

(4) percent monocytes

(5) absolute neutrophil count in 10^9/L

(6) percent neutrophils

(6) serum total bilirubin in µmol/L

(7) serum ALT in U/L

(8) serum uric acid in µmol/L

(9) serum cystatin C in mg/L

 

Parameter

Points

platelet count

0.8236 * (count)

packed cell volume

-0.6823 * (PCV)

absolute lymphocyte count

-0.4442 * (count)

percent monocytes

-0.272 * (percent)

absolute neutrophil count

0.0222 * (count)

percent neutrophils

0.0027 * (percent)

serum total bilirubin

-0.5511* (bilirubin)

serum ALT

-0.6839 * (ALT)

serum uric acid

0.6198 * (uric acid)

serum cystatin C

0.6040 * (cystatin)

 

Interpretation:

• The risk score varies with the inputs.

• The range reported by Zhan et al was 0 to 2.8. The values from the above is about 200 times greater. This primarily based on points assigned for the platelet count and uric acid.

• If log transforms were performed on platelet count, bilirubin, ALT and uric acid then values close to this shown by Zhan are seen.

• The hazard ratio for the score was 4.98.


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