Peralta et al evaluated patients with chronic kidney disease (CKD) using 3 markers (creatinine, cystin C, and the urine albumin-to-creatinine ratio). These can help to identify a patient who may progress to end-stage renal disease or die. The authors are from San Francisco VA Medical Center, University of California at San Francisco, University of Alabama, University of Vermont and Emory University.
Stage 3 to 5 chronic kidney disease was defined as an estimated GFR < 60 mL per min per 1.73 square meter BSA.
Markers:
(1) estimated creatinine clearance in mL per min per 1.73 square meter BSA
(2) cystin C clearance in mL per min per 1.73 square meter BSA
(3) urine albumin-to-creatinine ratio in mg per g on a spot urine
Marker |
Normal |
Abnormal |
creatinine clearance in mL per min per 1.73 sq m |
>= 60 |
< 60 |
cystin C clearance in mL per min per 1.73 sq m |
>= 60 |
< 60 |
urine albumin-to-creatinine ratio in mg/g |
< 30 |
>= 30 (albuminuria) |
Creatinine Clearance |
Cystin C Clearance |
Urine Albumin to Creatinine Ratio |
Mortality Per 1,000 Patient Years |
normal |
normal |
normal |
9.5 |
normal |
normal |
abnormal |
23 |
normal |
abnormal |
normal |
41 |
normal |
abnormal |
abnormal |
64 |
abnormal |
normal |
normal |
10.2 |
abnormal |
normal |
abnormal |
44 |
abnormal |
abnormal |
normal |
44 |
abnormal |
abnormal |
abnormal |
79 |
Creatinine Clearance |
Cystin C Clearance |
Urine Albumin to Creatinine Ratio |
End-Stage Renal Disease Per 1,000 Patient Years |
normal |
normal |
normal |
0.1 |
normal |
normal |
abnormal |
1.1 |
normal |
abnormal |
normal |
0.7 |
normal |
abnormal |
abnormal |
6.3 |
abnormal |
normal |
normal |
0.2 |
abnormal |
normal |
abnormal |
1.4 |
abnormal |
abnormal |
normal |
2.8 |
abnormal |
abnormal |
abnormal |
34 |
Specialty: Nephrology, Clinical Laboratory
ICD-10: ,