People who eat squirrel brains rarely can develop transmissible spongiform encephalopathy (TSE, variant prion disease). The diagnosis may be delayed which impacts attempts to control the disease.
Clinical features:
(1) The patient has a history of eating squirrel brains.
(2) Other sources of prion disease excluded.
(3) The patient develops a spongioform encephalopathy with cognitive decline.
Protein 14-3-3 may be found in the CSF.
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