Tu et al reported 2 noninvasive scores for predicting the histologic stage of a patient with primary biliary cholangitis (PBC). The authors are from Jilin University and Qingdao Municipal Hospital in China.
TR score refers to total bile acids and RDW.
Patient selection: primary biliary cholangitis (PBC)
Fibrosis
Histologic Stage
portal inflammation
S1
interface hepatitis with bile duct hyperplasia
S2
fibrous septae
S3
cirrhosis
S4
Parameters:
(1) total bile acids in µmol/L
(2) RDW in percent
model S =
= (0.005 * (total bile acid)) + (0.176 * (RDW)) - 0.668
TR score =
= (TBA) * (RDW) / 10
Score
S2 to S4
S3 or S4
TR score
> 23.923
> 61.189
> 97.465
Model S
> 2.044
> 2.231
> 2.401
Performance:
• The area under ROC curve is 0.89 for predicting S3-S4.
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Specialty: Gastroenterology
