Description

Cherry et al correlated activity of enzymes involved in the metabolism of organophosphates with ill-health in farmers who dip sheep. Lower activity of paraoxonase (PON1) is associated with claims of ill health. The authors are from the University of Manchester and the Manchester Royal Infirmary.


 

Subjects: farmers who dip sheep in organophosphate pesticides

 

Enzyme studied: paraoxonase (PON1), which hydrolyses organophosphates

 

Risk factors associated with claims of ill health:

(1) decreased degradation of diazinonoxon (substrate used to demonstrate PON1 activity)

(2) LL genotype (2 alleles with leucine replacing methionine at position 55, vs LM and MM)

(3) RR or QR genotype (1 or 2 alleles with glutamine replacing arginine at position 192, versus QQ)

 


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