Viswanathan et al reported acute toxicities associated with radiation therapy for a gynecologic malignancy. The authors are from Dana Farber Cancer Institute, Washington University, Brigham and Women's Hospital, and Massachusetts General Hospital.
Period: more than 6 months after radiation therapy, sometimes 10 years or more
Chronic gastrointestinal toxicities:
(1) enteritis
(2) proctitis
(3) fistula
(4) bowel obstruction and/or stricture
Chronic urinary tract toxicities:
(1) cystitis
(2) fistula
(3) contracture
(4) strictures
Chronic gynecologic toxicities:
(1) vaginal stenosis
(2) menopause from ovarian failure
(3) sexual dysfunction
Chronic dermatologic toxicities:
(1) telangiectasia
(2) fibrosis
(3) ulceration
(4) necrosis
Chronic bone toxicities:
(1) osteopenia
(2) insufficiency fracture
(3) avascular necrosis
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