Description

Barium carbonate is used as a rat poison (rodenticide) in many parts of the world. A human may become intoxicated by accidental, homicidal or suicidal intake.


 

Chemical: BaCO3

 

Mechanism of intoxication:

(1) blockage of potassium channels in muscle

(2) intracellular accumulation of potassium

 

Fatal dose in the adult: 0.8 g (800 mg)

 

Key clinical findings: flaccid muscle paralysis

(1) with or without quadriparesis

(2) absence of deep tendon reflexes (areflexic)

 

Additional clinical features:

(1) blurred vision

(2) trismus

(3) excessive salivation

(4) difficulty speaking and swallowing

(5) nausea and vomiting

(6) diarrhea

(7) abdominal pain

(8) tenesmus

(9) cardiac arrhythmias with an irregular pulse

(10) rhabdomyolysis

(11) respiratory failure

 

Laboratory findings:

(1) severe hypokalemia

(2) evidence of barium in stool, urine or blood

 

Differential diagnosis:

(1) Guillain-Barre syndrome

 


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