Topiramate is an entiepileptic drug that can cause transient hypohidrosis occasionally. It may be caused by inhibition of carbonic anhydrase in ecrrine sweat glands (Cerminara et al).


Clinical features:

(1) The patient is being treated with topiramate.

(2) The patient develops:

(2a) reduced sweating

(2b) hyperthermia

(2c) dry skin

(3) Reduced or absent sweat production during in vivo sweat testing.

(4) The hypohydrosis reverses after the drug is discontinued.

(5) There is no alternative explanation for the hypohidrosis.


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