Heianza et al developed a score to screen for undiagnosed diabetes in Japanese adults. The authors are from multiple hospitals in Japan and TOPICS refers to the Toranomon Hopital Health Management Center.
Patient: Japanese adult without known diabetes
Parameters:
(1) age in years
(2) gender
(3) body mass index (BMI)
(4) family history (siblings, parents) of diabetes
(5) current smoking
(6) hypertension (systolic blood pressure > 140 mm Hg OR diastolic blood pressure > 90 mm Hg OR medical treatment for hypertension)
|
Parameter |
Finding |
Points |
beta coefficient |
|
age in years |
< 40 years |
0 |
0 |
|
|
40 to 49 years |
3 |
1.09 |
|
|
50 to 59 years |
4 |
1.68 |
|
|
>= 60 years |
5 |
2.09 |
|
gender |
female |
0 |
0 |
|
|
male |
2 |
0.93 |
|
BMI |
< 23 kg per sq m |
0 |
0 |
|
|
23 to 24 |
1 |
0.27 |
|
|
25 to 29 |
2 |
0.82 |
|
|
>= 30 |
4 |
1.82 |
|
family history |
no |
0 |
0 |
|
|
yes |
2 |
0.85 |
|
current smoking |
no |
0 |
0 |
|
|
yes |
1 |
0.35 |
|
hypertension |
no |
0 |
0 |
|
|
yes |
2 |
0.68 |
total score =
= SUM(points for all 6 parameters)
X =
= SUM(points for beta coefficients) - 6.59
probability of diabetes =
= 1 / (1 + EXP((-1) * X))
Interpretation:
• minimum score: 0
• maximum score: 16
• The higher the score the greater the risk for diabetes.
• A score >= 8 was considered positive for the screening test.
Performance:
• The area under the ROC curve was 0.77.
• For a score >= 8 the sensitivity was 73% and specificity 68%.
Specialty: Endocrinology, Clinical Laboratory
ICD-10: ,
