TNM Classification for Hepatocellular Carcinoma

Number of Tumor Nodules

Size of Largest Tumor Nodule

Other

T Code

1

<= 2 cm

without vascular invasion

T1

1

<= 2 cm

with vascular invasion

T2

1

> 2 cm

without vascular invasion

T2

1

> 2 cm

with vascular invasion

T3

> 1 in one lobe

<= 2 cm

without vascular invasion

T2

> 1 in one lobe

<= 2 cm

with vascular invasion

T3

> 1 in one lobe

> 2 cm

without vascular invasion

T3

> 1 in one lobe

> 2 cm

with vascular invasion

T3

> 1 in more than 1 lobe

T4

>= 1

involvement of major branch of portal or hepatic vein

T4

>= 1

invasion of adjacent organs other than gallbladder

T4

>= 1

perforation of visceral peritoneum

T4

Site

Finding

Code

regional lymph nodes

no metastases present

N0

metastases present

N1

distant sites

no metastases present

M0

metastases present

M1

TNM

Stage

T1 N0 M0

I

T2 N0 M0

II

T3 N0 M0

IIIA

T1 – T3, N1, M0

IIIB

T4, any N, M0

IVA

any T, any N, M1

IVB