Some patients with hemophilia A (hereditary Factor VIII deficiency) will develop Factor VIII inhibitors. These may interfere with the effectiveness of Factor VIII replacement.
A patient with an inhibitor can be classified as a low or high responder depending on
(1) the titer of the inhibitor and
(2) the change in titer with time after exposure to Factor VIII replacement
Titer of the Inhibitor
Change in Titer with Time
no rise in titer with exposure
low to high
marked rise with exposure (anamnestic response)
• For the implementation I used an intermediate category for someone who does not meet the criteria for either responder group.
A low responder can usually be treated with Factor VIII replacement without problems.
A high responder with a high titered inhibitor may be difficult to treat since any Factor VIII is inactivated by the inhibitor.
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Purpose: To evaluate a patient with Hemophilia A (hereditary Factor VIII deficiency) for the level of anti-Factor VIII inhibitor.
Specialty: Hematology Oncology, Clinical Laboratory
Objective: laboratory tests, administration, response to therapy