The Thrombolysis In Myocardial Infarction (TIMI) trial used a grading scale to describe perfusion through a coronary artery, typically after thrombolysis.


Angiographic Findings

Perfusion Status


no antegrade flow beyond the point of occlusion

no perfusion


contrast material passes beyond the area of obstruction but fails to opacify the entire coronary bed distal to the obstruction for the duration of the cineangiographic filming ("hangs up")

penetration without perfusion


contrast material passes across the obstruction and opacifies the coronary bed distal to the obstruction; the rate of entry of contrast material into the vessel distal to the obstruction and/or its rate of clearance from the distal bed are perceptibly slower than its entry or clearance from comparable areas not perfused by the previously occluded vessel

partial perfusion


antegrade flow into the bed distal to the obstruction occurs as promptly as antegrade flow into the bed proximally to the obstruction; clearance of contrast material from the involved bed is as rapid as clearance from an uninvolved bed in the same vessel or the opposite artery

complete perfusion






0 or 1

closed artery (no myocardial perfusion)

2 or 3

open artery with complete perfusion within at least 3 cardiac cycles


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