Norris et al reported the Thrombogyn Score for predicting the risk of venous thromboembolism in a woman with a gynecologic cancer. The authors are from Trinity College Dublin, University College Cork and St. James's Hospital Dublin.
Patient selection: woman with a gynecologic cancer
Parameters:
(1) hemoglobin in g/dL
(2) body mass index (BMI) in kg per square meter
(3) chemotherapy
Additional biomarkers:
(4) D-dimer in ng/mL
(5) area under the thrombin curve (ETP) nm thrombin per min
|
Parameter
|
Finding
|
Points
|
|
hemoglobin
|
>= 11.5 g/dL
|
0
|
|
|
< 11.5 g/dL
|
1
|
|
BMI
|
<= 30 kg per sq m
|
0
|
|
|
> 30 kg per sq m
|
1
|
|
chemotherapy
|
no
|
0
|
|
|
yes
|
1
|
|
D-Dimer
|
<= 75th percentile
|
0
|
|
|
> 75th percentile
|
1
|
|
ETO
|
<= 75th percentile
|
0
|
|
|
> 75th percentile
|
1
|
where:
• The 75th percentile for D-Dimer was 1274 ng/mL
• The 75th percentile for ETP was 2475 nm thrombin per min
Thrombogyn score =
= SUM(points for first 3 parameters)
extended Thrombogyn score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum Thrombogyn score: 0
• maximum Thrombogyn score: 3
• minimum extended Thrombogyn score: 0
• maximum extended Thrombogyn score = 5
|
Throbogyn Score
|
Thrombosis Risk
|
Percent Thrombosis
|
|
0
|
low
|
1.3%
|
|
1
|
intermediate
|
7%
|
|
2 or 3
|
high
|
17.6%
|
